Endocrine Abstracts

Introduction: Lenvatinib is a multitarget tyrosine kinase inhibitor that has shown substantial efficacy in patients with progressive radioiodine refractory thyroid cancer (RAIRDTC) (progression free survival (PFS) 19.4 months and objective response rate 64.8%; SELECT trial) despite common adverse events (AEs).Objective: To evaluate efficacy and toxicity of lenvatinib treatment for RAIRDTC in daily clinical practice.Methods: Retrosp...

Introduction, material and methods: Papillary thyroid cancer is well known to be a tumour with a good prognosis; in spite of that, it usually presents many recurrences that increases its morbidity. Follicular thyroid cancer is less frequent but has a higher rate of hematogenous dissemination and higher mortality than papillary thyroid cancer. We have collected the data of our patients with differentiated thyroid cancer during the period from 2000 to 2015. In this study, we hav...

Small fish are excellent experimental models to screen endocrine-disrupting compounds, but current fish-based assays to detect endocrine disruption have not been standardized yet, meaning that there is not consensus on endpoints and biomarkers to be measured. Moreover, exposure conditions may vary depending on the species used as the experimental model or the endocrine pathway evaluated. Another drawback is the fact that most methods to detect endocrine disruption rely on the ...

IntroductionMultifocality is a common finding in papillary thyroid carcinoma (PTC), but its biological significance is not well established. In some cases not all foci present the same histological pattern.ObjectiveTo study the different histological patterns and molecular profiles of multifocal PTC (mPTC).Material and methodsAll patients with a confirmed diagnosi...

Introduction: In addition to physiological causes, the hyperprolactinemia spectrum includes iatrogenesis, pituitary adenomas, various diseases and functional disorders. Hyperprolactinemia accurate etiological diagnosis is essential for appropriate treatment. Non-functioning pituitary incidentalomas occur in approximately 10% of the population and tiny microprolactinomas could be elusive to imaging by magnetic resonance (MRI). Therefore, the coincidence of hyperprolactinemia an...

Patients with impaired glucose metabolism, either prediabetes (preD) or type 2 Diabetes (T2D), and non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular events. Recent studies have shown a relationship between epicardial fat and myocardial ischemia.Objective: To determine whether hepatic fibrosis assessed by liver elastography (LE) or Fibrosis-4 (FIB-4) score correlates with epicardial fat volume quantified by computed tomo...

Background: To describe trends in the incidence and outcomes for vascular dementia in elderly patients with and without type 2 diabetes (T2DM) in Spain between 2004 and 2013.Methods: We used National Hospital Discharge Data to select all patients aged 70 years or over discharged from hospital with a vascular dementia primary diagnosis. Discharges were grouped by diabetes status (T2DM or non-diabetic). Incidence was calculated overall and stratified by di...

Introduction: MTC accounts for 5% of thyroid cancers and can occur sporadically or as part of the multiple endocrine neoplasia type 2 syndrome (MEN 2). The objective of our study is to evaluate the prognostic factors and outcomes of patients with MTC in the community setting.Methods: Retrospective descriptive multicenter study of patients with histological diagnosis of MTC. Descriptive, bivariate analyses (Student t for cuantitative and ...

Objective: To understand the factors associated with changes in thyroid nodule volume with previous benign citology.Material and Methods: This is a prospective single-center observational study. We included patients with a benign citology from March/2016 to May/2018 and ultrasound follow-up after 12–24 months. Initially we determined the nodule size (volume in ml), and its risk of malignancy was classified according to ATA 2015 criteria. Volume cha...

Introduction: Obesity is a global health challenge with more than 60% of the world´s population with obesity living in LMICs. Studies have demonstrated that women are more affected by obesity than men. However, the risk of obesity and obesity-related cardiometabolic diseases in women in LMICs have not been documented. The aims of this meta-analysis are: to evaluate the risk of obesity and obesity-related cardiometabolic disease in women compared to men in LMICs and to eva...